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Pharmacological activities of 1-2.
| antibacterial IC50 (μM) |
anticancer IC50 (μM) |
||||||
|---|---|---|---|---|---|---|---|
| cmpd. | MRSA | VREF | tuberculosis | meana | DU4475b | antimalarial IC50 (μM) | antifungal IC50 (μM)c |
| 1 | 2.1 | 4.5 | >100 | 8.8 | 3.9 | 68 | >600 |
| 2 | 7.8 | 31 | >100 | 39 | 19 | >100 | >600 |
Mean of 12 cell lines (see Supporting Information for details)
breast tumor cell line
Using amphotericin B-resistant Candida albicans
