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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Neurobiol Aging. 2007 Jul 20;30(2):257–265. doi: 10.1016/j.neurobiolaging.2007.05.025

Figure 2. Aβ-induced LTP impairment in the CA1 region of hippocampal slices and its reversal by P8A.

Figure 2

P8A reverses Aβ-induced LTP impairment in the CA1 region of hippocampal slices (n = 8 slices from 8 mice for P8A, 6 slices from 6 mice for Aβ, and 6 slices from 6 mice for vehicle). Both Aβ and P8A did not affect baseline transmission in experiments where no tetanus was applied (n = 3 slices from 3 mice both for P8A, Aβ and vehicle). The horizontal bar indicates the period during which Aβ (200 nM) and P8A (200 μg/ml) were added to the bath solution. The arrows indicate the time at which the theta-burst stimulation was applied in this and the following figures. Every fourth recording point is shown for clarity in this and the following figures. Values represent mean ± SEM (Two-way ANOVA F(1, 12)=10.64, P<0.01 for P8A + Aβ vs. Aβ alone).