Figure 7. Disorder-to-order transition upon complex formation in ubiquitin C-terminal hydrolase.

Structures of two forms of the hydrolase are shown to demonstrate the disordered region which becomes ordered upon complex formation. On the left side is the monomeric ubiquitin hydrolase (1UCH) with the residue at either end of the disordered region highlighted in red and shown with sidechains. On the right side is the complex between ubiquitin hydrolase and ubiquitin with the same residues highlighted in red and sidechains drawn. To trace the disordered region, the ordered region on the right has been mapped to the monomeric structure on the left using a superposition between the two structures and is shown as a silhouette.