Figure 4. Preservation of salivary flow rates 30 days after single γ-radiation exposure by myr-Akt1 or injection with IGF1.

Four-week old female FVB, myr-Akt1 and FVB mice injected with 5 µg recombinant IGF1 were exposed to 1 Gy γ-radiation. IGF1 injections were performed immediately prior to radiation exposure as described in Figure 3. Thirty days after exposure to γ-radiation total saliva was collected following carbachol injection as described in Figure 2. Statistical analysis was performed using multiple comparison testing in the SAS system. Results shown are from ten irradiated FVB mice, ten irradiated myr-Akt1 mice and eight IGF1 plus irradiation mice and graphed using the averages and SEM from all mice. Treatment groups with the same letters are not significantly different from each other.