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. 2009 Mar 2;4(3):e4667. doi: 10.1371/journal.pone.0004667

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A) Timeline for immunization and challenge. B) Influenza H5N1 virus specific serum IgG antibody titers at two weeks after priming by ELISA. Groups of mice (n = 6) were intranasally immunized with H5N1 VLPs (0.1 µg and 0.3 µg of HA as indicated). PBS is a mock control group of mice mock-immunized with buffer only. C) Serum IgG antibody titers to inactivated rgΔH5N1 influenza virus by ELISA at 2 weeks after boost immunization. Error bars indicate standard deviation. 0.1 µg HA and 0.3 µg HA indicate groups of mice immunized with H5N1 VLPs containing 0.1 µg and 0.3 µg of H5 HA respectively. * Fold increases in virus-specific antibody titers as compared to levels after priming.