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One-Pot Asymmetric Alkyl Addition/Diastereoselective Iodocyclopropanation (Scheme 5).
| entry | product | % ee (% y) | dra | entry | product | % ee (% y) | dra |
|---|---|---|---|---|---|---|---|
| 1 |
1a
|
99 (66) | > 20:1 | 5 |
1e
|
98 (74) | > 20:1 |
| 2 |
1b
|
95 (62) | > 20:1 | 6 |
1fb
|
99 (78) | > 20:1 |
| 3 |
1c
|
89 (79) | > 20:1 | 7 |
1g
|
98 (70) | > 20:1 |
| 4 |
1d
|
96 (56) | > 20:1 | 8 |
1h
|
96 (60) | > 20:1 |
Determined by 1H NMR analysis of the crude reaction mixture.
10 mol% MIB was used.
