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One-Pot Asymmetric Vinyl Addition/Diastereoselective Iodocyclopropanation from Scheme 6.
| entry | product | % ee (% y) | dra | entry | product | % ee (% y) | dra |
|---|---|---|---|---|---|---|---|
| 1 |
1i
|
92 (64) | > 20:1 | 5 |
1m
|
93 (80) | > 20:1 |
| 2 |
1j
|
94 (78) | > 20:1 | 6 |
1n
|
94 (52) | > 20:1 |
| 3 |
1k
|
86 (67) | > 20:1 | ||||
| 4 |
1l
|
87 (70) | > 20:1 | 7 |
1o
|
99 (50) | > 20:1 |
Determined by 1H NMR analysis of the crude reaction mixture.
