Figure 1.

Mapt deletion decreases litter size of NPC1-deficient mice. (A) Litter sizes (mean±SEM) generated by Npc1+/− mice, stratified by parental Mapt genotype. Npc1+/− and Mapt−/− breedings generated fewer pups on average (P = 0.0002 by ANOVA with Newman–Keul's multiple comparison test) than mice with at least one functional Mapt allele (n, number of litters). (B) Npc1 null allele distribution in pups generated by NPC1 haploinsufficient mice, stratified by parental Mapt genotype. The percentage of NPC1/tau double null pups generated by Npc1+/−; Mapt−/− breeding was not significantly different from expected (P = 0.2 by χ² analysis) (n, number of mice). (C) Litter size (mean±SEM) of wild-type (black bar) and Mapt−/− (white bar) mice. N, number of litters; n.s., not significant (P > 0.05) by unpaired Student's t-test.