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. 2008 Dec 12;18(5):956–965. doi: 10.1093/hmg/ddn423

Figure 2.

Figure 2.

Decreased weight and early death of NPC1/tau double null mutant mice. (A) Weight (mean±SEM) of 5-week-old female (left panel) and male (right panel) mice. A significant difference between NPC1 single nulls (Npc1−/− and Mapt+/+), and NPC1 nulls haploinsufficient or deficient in tau was observed in females, whereas all Npc1−/− males were observed to have decreased weights when compared with wild-type and Mapt−/− controls. *, ** and *** signify P-values of <0.05, <0.01 and <0.001, respectively, by ANOVA with Newman–Keul's multiple comparison test. (B) Survival curve. Npc1−/−; Mapt +/− (green line) and Npc1−/−; Mapt−/− (blue line) were significantly different (P < 0.0001 by log-rank test) from wild-type, Mapt null (black line) and Npc1−/−; Mapt +/+ (red line) mice. (C) Age at death for Npc1−/−; Mapt +/+ (red triangles), Npc1−/−; Mapt +/− (blue squares) and Npc1−/−; Mapt−/− (black triangles) mice.