Skip to main content
. Author manuscript; available in PMC: 2010 Jan 28.
Published in final edited form as: J Am Chem Soc. 2009 Jan 28;131(3):1187–1194. doi: 10.1021/ja808108q

Figure 7.

Figure 7

Thermally-induced strand cleavage of w836 DNA (146 bp, nucleotide no. 5189–91) after DNA–agent incubation with yatakemycin and iso-yatakemycin (48 h, 23 °C), removal of unbound agent by EtOH precipitation and 30 min thermolysis (100 °C), followed by denaturing 8% PAGE and autoradiography. Lane 1, control DNA; lanes 2–5, Sanger G, C, A, and T sequencing standards; lane 6, (+)-yatakemycin (3, 1 × 10−6 M); lane 7, (+)-iso-yatakemycin (6, 1 × 10−6 M).