TABLE 3.

Total serum bilirubin among women and men stratified by UGT1A1 genotype and daily servings of foods assessed by 3DFR: interaction of genotype and diet¹

	Women				Men
Botanical family servings, n/d	6/6	6/7	7/7	P-interaction2	6/6	6/7	7/7	P-interaction2
Total botanicals	μmol/L				μmol/L
<4	10.4 (8.9, 12.0)	13.9 (12.2, 15.9)	18.6 (14.2, 24.5)	0.74	11.0 (9.2, 13.1)	17.6 (15.4, 20.2)	28.2 (21.5, 37.1)	0.53
	n = 18	n = 12	n = 2		n = 16	n = 16	n = 4
4–5	10.0 (9.2, 10.9)	13.7 (12.7, 14.7)	18.7 (16.0, 21.7)		11.5 (10.4, 12.6)	17.7 (16.3, 19.1)	27.3 (23.3, 32.0)
	n = 8	n = 11	n = 7		n = 10	n = 6	n = 4
>5	9.6 (8.7, 10.7)	13.4 (12.2, 14.7)	18.7 (15.5, 22.5)		11.9 (10.6, 13.4)	17.7 (16.0, 19.7)	26.4 (21.4, 32.5)
	n = 39	n = 30	n = 6		n = 39	n = 27	n = 7
Cruciferae
<0.5	9.8 (8.9, 10.8)	13.4 (12.3, 14.4)	18.2 (15.5, 21.3)	0.78	11.3 (10.2, 12.5)	17.4 (16.0, 19.0)	26.9 (22.8, 31.9)	0.45
	n = 50	n = 41	n = 12		n = 52	n = 37	n = 13
0.5+	10.2 (8.5, 12.2)	14.3 (12.3, 16.5)	20.0 (14.9, 26.8)		13.2 (10.7, 16.4)	18.5 (15.4, 22.2)	25.9 (17.9, 37.5)
	n = 15	n = 12	n = 3		n = 13	n = 12	n = 2
Rosaceae
<0.5	10.4 (9.2, 11.8)	13.5 (12.2, 14.9)	17.4 (14.3, 21.1)	0.22	11.8 (10.3, 13.5)	18.2 (16.2, 20.4)	28.0 (22.3, 35.1)	0.86
	n = 26	n = 23	n = 8		n = 32	n = 28	n = 6
0.5+	9.5 (8.5, 10.6)	13.8 (12.5, 15.2)	19.9 (16.3, 24.2)		11.4 (9.9, 13.0)	17.2 (15.4, 19.3)	26.1 (21.1, 32.2)
	n = 39	n = 30	n = 7		n = 33	n = 21	n = 9
Solanaceae
<0.5	10.0 (8.9, 11.3)	13.7 (12.1, 15.4)	18.6 (14.7, 23.7)	0.94	10.7 (9.1, 12.6)	18.1 (16.0, 20.5)	30.6 (24.1, 38.9)	0.11
	n = 30	n = 17	n = 5		n = 21	n = 19	n = 6
0.5+	9.8 (8.8, 11.0)	13.5 (12.4, 14.7)	18.5 (15.6, 22.1)		12.1 (10.8, 13.5)	17.4 (15.7, 19.2)	25.0 (20.5, 30.4)
	n = 35	n = 36	n = 10		n = 44	n = 30	n = 9
Leguminosae
<0.5	10.1 (8.8, 11.6)	13.2 (11.6, 15.1)	17.3 (13.3, 22.4)	0.47	11.3 (9.8, 13.1)	17.5 (15.5, 19.9)	27.1 (21.2, 34.6)	0.81
	n = 26	n = 14	n = 4		n = 27	n = 21	n = 6
0.5+	9.8 (8.8, 10.9)	13.7 (12.6, 14.8)	19.1 (16.2, 22.5)		11.8 (10.5, 13.3)	17.8 (16.1, 19.8)	26.9 (22.1, 32.8)
	n = 39	n = 39	n = 11		n = 38	n = 28	n = 9
Rutaceae
<0.5	9.3 (8.4, 10.3)	13.7 (12.6, 14.8)	20.0 (17.1, 23.5)	0.03	11.2 (9.9, 12.7)	17.7 (16.0, 19.6)	28.1 (23.0, 34.2)	0.37
	n = 39	n = 39	n = 11		n = 37	n = 29	n = 9
0.5+	11.0 (9.6, 12.6)	12.8 (11.2, 14.8)	15.0 (11.4, 19.9)		12.2 (10.6, 14.1)	17.7 (15.6, 20.0)	25.5 (20.0, 32.5)
	n = 26	n = 14	n = 4		n = 28	n = 20	n = 6
Umbelliferae
<0.5	10.0 (9.1, 10.9)	13.8 (12.7, 14.9)	19.0 (16.3, 22.1)	0.77	11.9 (10.8, 13.2)	17.4 (16.0, 19.0)	25.4 (21.4, 30.2)	0.08
	n = 55	n = 39	n = 14		n = 56	n = 41	n = 11
0.5+	9.6 (7.8, 11.8)	12.7 (10.7, 15.1)	16.8 (11.7, 24.3)		10.2 (8.0, 12.9)	18.5 (15.5, 22.0)	33.6 (24.5, 46.1)
	n = 10	n = 14	n = 1		n = 9	n = 8	n = 4

¹Bilirubin data were transformed ln(x+1). Back-transformed means and 95% CI (in parentheses) are presented.

²Adjusted for race, age, and total energy (total botanicals) or total botanicals (models for all other botanical families) using multiple linear regression.