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. Author manuscript; available in PMC: 2009 Oct 9.
Published in final edited form as: J Med Chem. 2008 Sep 11;51(19):6034–6043. doi: 10.1021/jm800510m

Scheme 1.

Scheme 1

Synthesis of 2, 3, and radiotracer [11C]3.a

a Reagents, conditions and yields: (i) DIPEA, MeCN, 70 °C, 31 h, yield 69%; (ii) KOH, tBuOH, 100 °C, 3 d, yield 37%; (iii) [11C]MeI, KOH, DMSO, 80 °C, 5 min, RCY 18% from [11C]carbon dioxide; (iv) MeI, KOH, DMSO, 80 °C, 24 h, 3%.