Skip to main content
. Author manuscript; available in PMC: 2009 Feb 23.
Published in final edited form as: Biochem Biophys Res Commun. 2007 Mar 19;358(1):1–6. doi: 10.1016/j.bbrc.2007.03.056

Table 1.

Hits and false positives obtained from the screening.

Cpd Class Cpd Name Structure % Inhib. (ThT)a Sed. Assayb % Inhib. (ThT) No DTT Sed. Assay No DTT IC50 (μM)
Antraquinones 31G03 graphic file with name nihms24051t1.jpg 76 ++ 39 - 0.63
Quinoxalines 113F08 graphic file with name nihms24051t2.jpg 69 ++ 70 +++ 2.4
330B06 graphic file with name nihms24051t3.jpg 27 +++ 85 ++ 3.1
Pyrimidotriazines 300C04 graphic file with name nihms24051t4.jpg 94 +++ 20 - 0.36
Sulfonated Dyes 6C06 graphic file with name nihms24051t5.jpg 102 +++ 51 - 3.2
Depsidones 15B02 graphic file with name nihms24051t6.jpg 98 +++ 100 +++ 1.6
Porphyrins 06D04 graphic file with name nihms24051t7.jpg 75 +++ -2.6 nd 4.5
Phenothiazines 30H07 graphic file with name nihms24051t8.jpg 100 +++ 99 nd 0.29
Benzofuran 348E10 graphic file with name nihms24051t9.jpg 84 +++ 9.8 nd 0.61
a

Percentage inhibition of K18 fibrillization followed by ThT assay;

b

Sedimentation assay data: “+++” = 100% inhibition, “-“ = 0% inhibition, IC50 determined in the presence of DTT. Additional hits from the pyrimidotriazines, 17H03 and 93D02, behaved similarly to 300C04 and are not shown.