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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Mol Cell Neurosci. 2008 Aug 15;39(3):452–464. doi: 10.1016/j.mcn.2008.07.026

Figure 4. Mutation of the O-fucosylation site on C45 muscle agrin stimulates AChR clustering.

Figure 4

(A) 1nM FLAG-tagged C45(z8), C45(z8)S1726A, C45(z0), or c45(z0)S1726A were assayed for AChR clustering on C2C12 myotubes by staining with rhodamine-α-bungarotoxin. Bar is 50µm. (B) C45(z0)S1726A, C45(z8), and C45(z8)S1726A agrin showed similar concentration curves for the induction of AChR clustering, while C45(z0) agrin had no activity. Errors are SEM for n=6 experiments.