Table 2.

Multivariable regression analysis of factors associated with the involvement of MDR pathogens in VAP (n = 192).

Predictor	Parameter estimate	OR	CI	p value
Enter method
Age	0.01	1.01	0.99 to 1.03	0.23
Charlson index	0.85	1.09	0.93 to 1.27	0.28
Coma on ICU admission	-0.83	0.44	0.19 to 1.03	0.06
ARDS before VAP	0.52	1.69	0.86 to 3.31	0.13
RRT before VAP	-0.42	0.66	0.31 to 1.42	0.29
Duration of hospitalisation before VAP	0.006	1.01	1.00 to 1.02	0.20
One antibiotic before VAP	0.06	1.06	0.39 to 2.92	0.90
Two antibiotic classes before VAP	0.85	2.34	0.82 to 6.71	0.11
More than two antibiotic classes before VAP	1.37	3.93	1.26 to 12.23	0.02
Constant	-2.72
Backward stepwise
Coma on ICU admission	-1.12	0.32	0.14 to 0.73	0.01
Two antibiotic classes before VAP	0.88	2.41	1.22 to 4.79	0.01
More than two antibiotic classes before VAP	1.50	4.47	2.15 to 9.31	< 0.001
Constant	-1.50

Overall correct prediction: 77%.

Hosmer-Lemeshow goodness-of-fit: Chi-square 4.74, p = 0.8, eight degrees of freedom. ROC curve: area under the curve = 0.80 (0.73 to 0.86).

ARDS = acute respiratory distress syndrome; CI = confidence interval; ICU = intensive care unit; MDR = multidrug resistant; OR = odds ratio; RRT = renal replacement therapy; VAP = ventilator-associated pneumonia.