Table 2.

Univariate and multivariate Cox regression analysis

	Univariate			Multivariate
Variables	HR	95% CI	p value	HR	95% CI	P value
Age (years)	1.528	0.694 to 3.364	0.288
Gender (m/f)	1.007	0.983 to 1.031	0.577
Sepsis (yes/no)	2.688	0.918 to 7.874	0.072	1.004	0.154 to 6.553	0.997
MAP (mmHg)	0.981	0.954 to 1.009	0.186
Heart rate (bpm)	0.995	0.976 to 1.014	0.583
Noradrenaline (μg/kg/min)	1.433	0.695 to 2.954	0.330
FiO2 (%)	1.002	0.980 to 1.025	0.873
PaO2/FiO2	1.001	0.997 to 1.005	0.737
CRP (mg/L)	0.998	0.995 to 1.002	0.364
Lactate (mmol/L)	1.105	1.029 to 1.185	0.006*	1.064	0.986 to 1.148	0.111
APACHE II score	1.060	1.012 to 1.110	0.013*	1.040	0.985 to 1.099	0.154
SOFA score	1.107	1.006 to 1.219	0.038*	1.073	0.971 to 1.185	0.167
VEGF (pg/ml)	1.000	0.997 to 1.004	0.962
Ang-1 (ng/ml)	1.010	0.918 to 1.111	0.840
Ang-2 (ng/ml)a	1.034	1.013 to 1.056	0.001*	1.033	1.012 to 1.055	0.002*
Ang-2 (log10)a	4.383	1.628 to 11.802	0.003*	4.284	1.627 to 11.281	0.003*
Ang-2/Ang-1 (log10)a	2.630	1.207 to 5.729	0.015*	2.384	1.061 to 5.360	0.036* b

*p < 0.05.

^a tested separately from each other;

^b In this model APACHE II remained significant in the multivariate model (p = 0.039).

Ang = Angiopoietin; APACHE II = Acute Physiology and Chronic Health Evaluation II; CI = confidence interval; CRP = C-reactive protein; f = female; FiO₂ = fraction of inspired oxygen; HR = heart rate; m = male; MAP = mean arterial pressure; PaO₂ = partial pressure of oxygen in arterial blood; SOFA = Sequential Organ Failure Assessment; VEGF = vascular endothelial growth factor.