Table 1.
Systemic variables
| Group | Baseline | 12 hours | 18 hours | 22 hours | |
| MAP | Control | 91 (86 to 95) | 82.5 (71 to 88) | 77 (70 to 81) | 77 (64 to 85) |
| (mmHg) | AKI | 94 (89 to 97) | 80 (72.5 to 93) | 75 (68 to 83)* | 72 (66 to 76)* |
| MPAP | Control | 25 (20 to 26) | 26 (23 to 27) | 25 (24 to 26) | 26 (25 to 29) |
| (mmHg) | AKI | 24 (21 to 28) | 31 (28 to 37)*§ | 42 (34 to 46)*§ | 44 (41 to 47)*§ |
| CO | Control | 92 (83 to 110) | 98 (88 to 109) | 87 (79 to 100) | 88 (79 to 102) |
| (ml/kg) | AKI | 79 (64 to 102) | 113 (95 to 164)§ | 140 (116 to 178)*§ | 174 (120 to 191)*§ |
| SVR | Control | 2697 (1508 to 2914) | 2007 (1913 to 2093) | 1930 (1876 to 1965) | 1950 (1670 to 2289) |
| (dyne.s.cm-5) | AKI | 2595 (1972 to 2809) | 1523 (968 to 1917)*§ | 964 (683 to 1263)*§ | 757 (600 to 852)*§ |
| CVP | Control | 8 (8 to 9) | 11 (10 to 13)* | 13 (12 to 15)* | 13 (12 to 15)* |
| (mmHg) | AKI | 10 (9 to 13) | 13 (12 to 15)* | 16 (14 to 18)* | 18 (16 to 19)*§ |
| PAOP | Control | 8 (7 to 10) | 11 (8 to 12) | 12 (10 to 13) | 12 (10 to 17) |
| (mmHg) | AKI | 10 (9 to 12) | 12 (11 to 15)* | 16 (14 to 17)*§ | 16 (16 to 17)* |
| DO2 | Control | 11 (11 to 12) | 11 (9 to 12) | 10 (9 to 12) | 10 (9 to 12) |
| (ml/min/kg) | AKI | 11 (9 to 13) | 16 (14 to 27)§ | 16 (14 to 19)§ | 19 (11 to 25) |
| VO2 | Control | 5 (4 to 6) | 6 (5 to 6) | 5 (5 to 6) | 5 (5 to 5) |
| (ml/min/kg) | AKI | 5 (5 to 6) | 6 (5 to 8) | 6 (5 to 6) | 6 (5 to 8) |
| pH | Control | 7.58 (7.55 to 7.59) | 7.56 (7.52 to 7.58) | 7.57 (7.54 to 7.60) | 7.58 (7.50 to 7.61) |
| AKI | 7.54 (7.52 to 7.60) | 7.45 (7.43 to 7.49)*§ | 7.41 (7.20 to 7.47)*§ | 7.31 (7.08 to 7.36)*§ | |
| IL-6 | Control | 2 (1 to 3) | 1 (0 to 1) | 1 (0 to 1) | 1 (0 to 2) |
| (pg/ml/g protein) | AKI | 4 (1 to 8) | 41 (29 to 201)*§ | 240 (111 to 602)*§ | 384 (163 to 1405)*§ |
| TNF-α | Control | 0 (0 to 0) | 1 (1 to 2) | 2 (1 to 2) | 1 (1 to 2) |
| (pg/ml/g protein) | AKI | 1 (1 to 2) | 10 (5 to 16)*§ | 17 (8 to 28)*§ | 21 (8 to 33)*§ |
| TBARS | Control | 17 (16 to 19) | 19 (17 to 28) | 22 (19 to 30) | 23 (16 to 25) |
| (nmol/g protein) | AKI | 18 (15 to 24) | 63 (44 to 93)*§ | 90 (71 to 117)*§ | 78 (68 to 108)*§ |
| Plasma nitrate+nitrite levels | Control | 1 (1 to 1) | 1 (0 to 1)* | 1 (0 to 1)* | 1 (1 to 1) |
| (μmol/g protein) | AKI | 1 (1 to 1) | 1 (1 to 2)*§ | 2 (1 to 2)*§ | 1 (1 to 2)* |
CO = cardiac output, CVP = central venous pressure, DO2 = oxygen delivery, IL = interleukin, MAP = mean arterial pressure, MPAP = mean pulmonary artery pressure, PAOP = pulmonary artery occlusion pressure, SVR = systemic vascular resistance, TBARS = thiobarbituric acid reactive species, TNF = tumour necrosis factor, VO2 = oxygen uptake.
Control = sham operated group; AKI = peritonitis induced group
* significant difference within each group versus baseline (p < 0.05); §significant difference between groups (p < 0.05). Data are median and 25th and 75th quartiles.