. 2008 Nov 4;12(6):R135. doi: 10.1186/cc7108

Table 1.

Ventilation and respiratory system mechanics

		SB	Baseline ALI	Treatment	Lung injury	Time	Injury type	Mode	Inter-action
RR, breaths per minute	HCl	+	28.2 ± 3.4	45.3 ± 8.5^b	^a	^a		^a
		-	28.4 ± 2.8	28.3 ± 3.2^c
	OA	+	29.2 ± 0.1	43.5 ± 6.7^b
		-	29.1 ± 1.8	29.2 ± 1.7^c
V_T, mL	HCl	+	326 ± 46	212 ± 28^b
		-	303 ± 23	272 ± 20^b	^a	^a		^a	TM^a
	OA	+	317 ± 41	190 ± 19^b
		-	285 ± 52	260 ± 31^b
V_{T, sb}, mL	HCl	+	n/a	135 ± 20			^a
		-	n/a	n/a
	OA	+	n/a	95 ± 19^d
		-	n/a	n/a
V_E, liters	HCl	+	8.8 ± 1.1	8.6 ± 1.5	^a	^a		^a
		-	8.5 ± 0.9^c	7.6 ± 1.1^c
	OA	+	9.1 ± 1.2	7.7 ± 1.2
		-	8.0 ± 1.0^c	7.4 ± 0.6^c
PaCO₂, mm Hg	HCl	+	40 ± 6	45 ± 9	^a	^a		^a	TM^a
		-	42 ± 9	54 ± 13^c
	OA	+	41 ± 9	43 ± 10
		-	46 ± 10	54 ± 17^c
P_{transp, mean}, mbar	HCl	+	5.5 ± 3.0	5.5 ± 4.6	^a	^a	^a
		-	6.8 ± 3.3	8.1 ± 3.4
	OA	+	2.1 ± 3.0	2.7 ± 3.4
		-	0.5 ± 3.2	3.1 ± 3.5
PEEP_{I, dyn}, mbar	HCl	+	0.0 ± 1.1	0.3 ± 0.3
		-	0.7 ± 0.6	0.9 ± 0.9
	OA	+	0.0 ± 1.6	0.8 ± 0.5
		-	0.3 ± 0.3	0.0 ± 1.6
C_cw, mL/mbar	HCl	+	89.3 ± 39.3	n/a			^a
		-	96.8 ± 34.9	115.5 ± 64.3
	OA	+	40.9 ± 14.8^d	n/a
		-	39.3 ± 11.2^d	49.5 ± 27.6^d
C_lung, mL/mbar	HCl	+	19.5 ± 4.0	n/a	^a		^a
		-	16.4 ± 8.4	13.5 ± 2.8
	OA	+	21.3 ± 4.7^d	n/a
		-	21.7 ± 8.3^d	16.2 ± 7.9^d
R, mbar/L per second	HCl	+	7.0 ± 0.7^b	n/a			^a	^a
		-	7.5 ± 1.6^b	8.5 ± 2.8
	OA	+	8.5 ± 1.0^b	n/a
		-	9.0 ± 3.0^b	11.9 ± 2.7
EELV, mL	HCl	+		606 ± 171			^a	^a
		-		372 ± 130^c
	OA	+		439 ± 90^d
		-		192 ± 51^{c, d}

Pre-acute lung injury (ALI) (Table S2 in additional data file 1) was tested only against baseline ALI. Post hoc testing was always performed if a significant F ratio for a factor or the interaction of factors was obtained by repeated measures analysis of variance (^aP < 0.05), but only significant differences are marked: ^bP < 0.05 for within-group differences (ALI versus Treatment), ^cP < 0.05 for between-group differences (PCV + SB versus PCV – SB), and ^dP < 0.05 for between-group differences (HCl-ALI versus OA-ALI) (post hoc Tukey multiple comparison test). +, pressure-controlled ventilation with maintained spontaneous breathing; -, pressure-controlled ventilation without spontaneous breathing; C_cw, chest wall compliance; C_lung, lung compliance; EELV, end-expiratory lung volume; HCl, hydrochloric acid-induced acute lung injury; M, mode; n/a, not applicable; OA, oleic acid-induced acute lung injury; PaCO₂, arterial partial pressure of carbon dioxide; PCV + SB, pressure-controlled ventilation with spontaneous breathing; PCV – SB, pressure-controlled ventilation without spontaneous breathing; PEEP_{I, dyn}, dynamic intrinsic positive end-expiratory pressure; P_{transp, mean}, mean transpulmonary airway pressure; R, respiratory system resistance; RR, respiratory rate; SB, spontaneous breathing; T, time; V_E, minute ventilation; V_T, tidal volume; V_{T, sb}, tidal volume of spontaneous breaths.