Table 1. Statistical analysis of total tumor volume means using the SAS system, PROC MIXED procedures.

Column I			Column II
Group*	Day**	Mean Tumor Volume (cm3)***	Group*	Day**	Mean Tumor Volume (cm3)***	Group Comparisons:Column I to Column II p-value (Pr > [t])
A	12	0.155 ± 0.06	B	12	0.114 ± 0.05	0.1899
A	12	0.155 ± 0.06	C	12	0.042 ± 0.03	<0.0001
A	12	0.155 ± 0.06	D	12	0.046 ± 0.02	<0.0001
A	12	0.155 ± 0.06	E	12	0.035 ± 0.02	<0.0001
A	12	0.155 ± 0.06	F	12	0.048 ± 0.02	0.0001
C	33	0.100 ± 0.12	D	33	0.114 ± 0.05	0.6316
C	33	0.100 ± 0.12	E	33	0.029 ± 0.02	0.0116
C	33	0.100 ± 0.12	F	33	0.040 ± 0.02	0.0345
D	33	0.114 ± 0.05	E	33	0.029 ± 0.02	0.0023
D	33	0.114 ± 0.05	F	33	0.040 ± 0.02	0.0084

Comparison (Differences of Least Square Means) of study group from Column I to study group in Column II on a select day of the study. Comparison of study groups evaluates for statistically significant difference in total tumor volumes (p-value < 0.05, two tailed).

^*Groups as follows: A = Control; B = Docetaxel + Estramustine; C = Docetaxel; D = Targeted-Radiotherapy (TRT); E = TRT+ Docetaxel; F = TRT + Docetaxel + Estramustine.

^**Day refers to number of days post dose initiation (day 0).

^***Mean estimate ± SD (total tumor volume in cm³ per mouse). Standard error of statistical comparison of Column I and II is 0.020.