. Author manuscript; available in PMC: 2009 Nov 21.

Published in final edited form as: J Org Chem. 2008 Oct 22;73(22):8901–8920. doi: 10.1021/jo801312r

Table 2.

Anti-proliferation activities of quinoline- and naphthalene-containing novobiocin analogues.

Compound	R¹	R⁷	X	MCF-7	SkBr3	PC-3	LnCaP
42a	biaryl	4-OMe-Bn	N	> 100^a	> 100	> 100	> 100
42b	biaryl	H	N	13.1 ± 4.1	16.5 ± 6.2	17.6 ± 4.6	14.2 ± 0.4
42c	biaryl	4-OMe-Bn	CH	> 100	> 100	> 100	> 100
42d	biaryl	H	CH	46.4 ± 5.3	38.9 ± 2.4	10.9 ± 0.7	19.6 ± 1.6

Values represent mean ± standard deviation for at least two separate experiments performed in triplicate.