Figure 1.

(A) The synthetic steps used to prepare the encoded combinatorial chemical library on a polymeric support. (B) The distribution frequency of synthons in active compounds from the combinatorial library. (C) Compound 1 (N-[(1,3-benzodioxol-5-yl)methyl]-1-[6-chloro-2-(1H-imidazol-1-yl)pyrimidin-4-yl]piperazine-2-acetamide) is one of the compounds that was found by screening the library. Compound 2 is (N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]-4-(methoxycarbonyl)-piperazine-2-acetamide. Compound 3, tritiated on the propionamide moiety, is the analog used in the competitive binding assay (N-[(1,3-benzodioxol-5-yl)methyl]-4-(ethylcarbonyl)-1-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]piperazine-2-acetamide).