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Inhibition of dimer formation in RAW264.7 cells. The effects of inhibitor treatment on the iNOS monomer/dimer ratio in cells was determined by size-exclusion chromatography of lysates from cells grown in the presence (○) or absence (●) of compound 2. (A) Cytochrome c reductase activity (a property of both iNOS monomers and dimers). (B) iNOS activity, indicating the presence of active dimer. This figure shows one of two experiments, which gave similar results.
