TABLE 3.
OTHER SYNDROMES REPORTED IN CASES OF CONGENITAL ABERRANT TEARING (NOT THALIDOMIDE)
| SOURCE | SYNDROME | NO. OF CASES WITH ABERRANT TEARING | AGE/SEX | MOTILITY | CROCODILE TEARS | EMOTIONAL TEARING | 7TH NERVE PALSY | COMMENTS |
|---|---|---|---|---|---|---|---|---|
| Amaya and associates42 | 18 cases of Möbius sequence | 3 | (1) 3 mo/NI | Abduction deficit OU all* | 3 | NI | All* | (1) Microglossia |
| (2) 6 mo/NI | (2) Cerebellum hypoplasia | |||||||
| (3) 3½ yr/NI | (3) Foot and tongue; keratitis | |||||||
| Miller and Strömland43 | 25 cases of Möbius sequence | 6–7 | 2–7 yr/all M | Abduction deficit all* | 4 cases(3 with no emotional tearing) | Absent 5* (3 with crocodile) | All* | |
| Brik and Athayde46 | Wildervanck | 1 | 13 ½ yr/F | DS OU | OU | NI | 0 | Klippel-Feil; DS |
| Haciyakupoglu and associates47 | Wildervanck | 1 | 13 yr/NI | DS OU | OU | NI | NI | Developmental delay; Dandy-Walker; Klippel-Feil; deaf |
| Brodsky48 | Wildervanck | 1 | 5 mo/NI | DS OU | OS | Absent OU | L | Klippel-Feil; deaf; brain stem hypoplasia; kyphosis hyperreflexia |
| Guirgis and associates49 | Isotretinoin (Accutane) | 1 | 10 mo/NI | Ophthalmoplegia (restrictive) | OU | Absent OU | NI | Mother used isotretinoin early in pregnancy; middle and external ear anomalies; micrognathia; preauricular skin tags |
| Nigam50 | Treacher-Collins | 1 | 11½ yr/M | Normal | OU | NI | NI | Microtia; deaf |
| Preisch and associates51 | BOR | 2 | 32 yr/M | OD | NI | NI | Schirmer test negative OD, positive OS; patients are father and daughter | |
| 4 yr/F | OD | NI | NI | BOR syndrome; hearing |
BOR, branchio-oto-renal; DS, Duane syndrome; OU, both eyes; OD, right eye; OS, left eye; NI, no information; L, left side; ↑, increased; ↓, decreased
*
Inclusion criteria for Möbius sequence.