Table 2.

HRs for incident diabetes by treatment arm and genotype at ENPP1K121Q

Group	Basic model HR (95% CI)	P	Model with race/ethnicity HR (95% CI)	P	Model with race/ethnicity + BMI HR (95% CI)	P
Placebo	1.38 (1.08–1.76)	0.01	1.38 (1.04–1.83)	0.03	1.36 (1.02–1.80)	0.04
Metformin	1.08 (0.81–1.43)	0.60	1.10 (0.79–1.54)	0.57	1.09 (0.78–1.53)	0.60
Lifestyle	0.89 (0.63–1.25)	0.51	0.81 (0.55–1.21)	0.31	0.83 (0.56–1.24)	0.37

Estimates of HR are from a dominant genetic model (Q/X vs. K/K). All models are adjusted for age and sex. The interaction between treatment group and rs1044498 was nominally significant with P = 0.03.