Table 2.
Association of alleles and genotypes of TCF7L2 SNPs with AbnDM vs. AbpDM or normal controls (NC)
| AbnDM (n = 113) | AbpDM (n = 573) | NC (n = 305) | Odds ratio (95% confidence interval)
|
||||
|---|---|---|---|---|---|---|---|
| AbnDM vs. AbpDM | AbnDM vs. NC | AbnDM vs. (AbpDM + NC) | AbpDM vs. NC | ||||
| rs12255372 | |||||||
| Alleles | |||||||
| G | 144 (0.637) | 838 (0.731) | 458 (0.751) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| T | 82 (0.363) | 308 (0.269) | 152 (0.249) | 1.55 (1.15–2.09)a | 1.72 (1.24–2.38)a | 1.60 (1.20–2.15)a | 1.11 (0.88–1.39) |
| Genotypes | |||||||
| G/G | 47 (0.416) | 306 (0.534) | 170 (0.557) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| G/T | 50 (0.442) | 226 (0.394) | 118 (0.387) | 1.44 (0.93–2.22) | 1.53 (0.97–2.43) | 1.47 (0.97–2.24) | 1.06 (0.79–1.41) |
| T/T | 16 (0.142) | 41 (0.072) | 17 (0.056) | 2.54 (1.32–4.89)a | 3.40 (1.60–7.25)a | 2.79 (1.49–5.24)a | 1.34 (0.74–2.43) |
| rs7903146 | |||||||
| Alleles | |||||||
| C | 141 (0.624) | 840 (0.733) | 451 (0.739) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| T | 85 (0.376) | 306 (0.267) | 159 (0.261) | 1.66 (1.23–2.23)a | 1.71 (1.24–2.37)a | 1.67 (1.25–2.24)b | 1.03 (0.83–1.29) |
| Genotypes | |||||||
| C/C | 47 (0.416) | 308 (0.538) | 170 (0.557) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| C/T | 47 (0.416) | 224 (0.391) | 111 (0.364) | 1.38 (0.89–2.13) | 1.53 (0.96–2.45) | 1.43 (0.93–2.19) | 1.11 (0.83–1.50) |
| T/T | 19 (0.168) | 41 (0.072) | 24 (0.079) | 3.04 (1.63–5.67)b | 2.86 (1.45–5.67)a | 2.97 (1.64–5.38)b | 0.94 (0.55–1.61) |
a
P < 0.01.
b
P < 0.001 (by Fisher’s exact test).