Table 2.
Associations of newborn and maternal thyroid function with child cognition at ages 6 months and 3 yr
| β-Coefficienta for change in test score (95% CI)
|
|||
|---|---|---|---|
| VRM test | PPVT | WRAVMAs | |
| Newborn heelstick blood | |||
| T4 (μg/dl) | −0.5 (−0.9, −0.2) | 0.2 (−0.1, 0.5) | 0.1 (−0.2, 0.3) |
| Maternal thyroid function | |||
| History of diagnosed thyroid disease | 2.4 (−4.8, 9.6) | 7.1 (1.7, 12.4) | 1.2 (−4.0, 6.4) |
| TPO antibody >2.0 U/ml | 2.1 (−1.7, 5.8) | 2.6 (−0.4, 5.5) | 1.8 (−1.0, 4.6) |
| TSH >2.5 mU/liter | 1.2 (−3.0, 5.3) | 2.5 (−0.8, 5.7) | 0.7 (−2.4, 3.8) |
| T4 (μg/dl) | −0.04 (−0.8, 0.7) | −0.1 (−0.7, 0.5) | 0.004 (−0.6, 0.6) |
| Maternal first trimester diet | |||
| Dairy (daily serving) | 0.2 (−0.9, 1.2) | −0.4 (−1.2, 0.4) | −0.3 (−1.0, 0.4) |
| Fish (weekly serving) | 1.2 (0.1, 2.3) | −0.4 (−1.0, 0.4) | −0.5 (−1.2, 0.3) |
| Eggs (weekly serving) | 0.3 (−0.7, 1.2) | −0.2 (−0.9, 0.5) | −0.5 (−1.1, 0.2) |
| Iodine-containing vitamins (yes vs. no) | 1.9 (−3.9, 7.6) | 3.0 (−1.4, 7.5) | 1.9 (−2.3, 6.1) |
a
Estimates for VRM test are adjusted for child sex, gestational age, fetal growth z score, breast-feeding status at 6 months (formula only, mixed formula and breast milk, weaned from breast milk to formula, and breast milk only) and age at testing, as well as and maternal race/ethnicity, education, and PPVT score. Estimates for PPVT and WRAVMAs are adjusted for child sex, gestational age, fetal growth z score, total duration of breast-feeding in months, age at testing, and primary language, as well as maternal race/ethnicity, education, and PPVT score.