Table 1.
Genes differentially expressed in WAT tissue of 6-month-old CD1 WT and VDRKO mice identified by PCR-focused array
| Gene name | Fold change VDRKO/WT | Pathway |
|---|---|---|
| Ucp-1 | 26.7 | Thermogenesis |
| Acetyl-coenzyme A carboxylase-α (acaca) | 26.2 | FAS |
| Glycerol-3-phosphate dehydrogenase (gpd1) | 25.2 | Glycerol degradation |
| Hexokinase (hk2) | 6.4 | Glycolysis/pentose shunt |
| LDL receptor (ldlr) | 5.7 | Lipid uptake |
| Akt2 | 5.5 | Insulin receptor signaling |
| Acyl-coA oxidase (acox1) | 4.2 | Fatty acid oxidation |
| Akt1 | 3.5 | Insulin receptor signaling |
| CCAAT/enhancer-binding protein-β | 3.4 | Transcription factor |
| Steroid regulatory element-binding protein (srebp1) | 2.7 | Transcription factor |
| Protein tyrosine phosphatase receptor type F (ptprf) | −3.6 | Intracellular signaling |
| Docking protein 1 (dok1, p62) | −4.5 | Insulin receptor signaling |