Figure 1.

Adiponectin effects on the membrane potential of NE and PA neurons in the PVN. A, Bath administration of 10 nm adiponectin (black bar) induces both depolarizing (i) and hyperpolarizing (ii) effects on membrane potential in different populations of type 3 NE neurons. Membrane potential routinely recovered to near control membrane potential (red line) after removal of adiponectin from the bath. B, Similar effects of adiponectin on membrane potential were seen in type 2 PA neurons, depolarizing (i) a population of cells while hyperpolarizing (ii) a separate group of neurons.