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. 2009 Feb 16;206(2):329–341. doi: 10.1084/jem.20081666

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Figure 1. — Abnormal histone H3K4 trimethylation at the Cd103, Rorc, and Il23r loci in Gfi1 cKO Th2 cells. CD4⁺ T cells from naive wild-type or Gfi1 cKO mice were activated under Th2 or Th17 conditions for 4 d. Cells were harvested and fixed. ChIP-Seq analysis was performed using a specific antibody against H3K4 trimethylation (H3K4me3). The sequence tags mapped to the locus of (A) Gata3, (B) Cd103, (C) Rorc, (D) Il23r, (E) Il21, and (F) Il17f are shown. The total tag numbers mapped to the genome are 2, 6, and 7.1 million for WT-Th17, Gfi1 cKO–Th2, and WT-Th2, respectively. The scale for the WT-Th17 sample was adjusted separately because of approximately threefold fewer total tag numbers.