(A). Ribbon diagram of the WNV E protein crystal structure. Domains are labeled and the fusion loop is shown in green. (B). Pseudoatomic model of the mature WNV virion based on cryo-electron microscopy studies. E protein domains I, II, and III are indicated in red, yellow and blue, respectively. Residues critical for binding of E16, a DIII-lr mAb, are shown in magenta. Adapted from (21, 68, 117).