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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Immunol Rev. 2008 Oct;225:212–225. doi: 10.1111/j.1600-065X.2008.00676.x

Fig. 2. Strongly neutralizing DIII-lr specific antibodies define a single consensus epitope that is divergent in other flaviviruses.

Fig. 2

(A). Sequence of the four segments of WNV DIII contacted by E16 aligned with the analogous residues of other flaviviruses. The DIII contact residues as determined by epitope mapping are highlighted in magenta, while those identified only structurally are highlighted in blue. Deletions are indicated with a hash symbol. (B). Structure of the WNV dominant neutralizing epitope as defined by the E16-DIII complex. Adapted from (68).