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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Immunol Rev. 2008 Oct;225:212–225. doi: 10.1111/j.1600-065X.2008.00676.x

Fig. 3. . Epitopes of several different anti-WNV neutralizing mAbs as determined by yeast surface display screening of E protein mutants.

Fig. 3

The backbone colors red, yellow, blue, and green indicate domains I, II, III, and the fusion loop respectively. Mutations that resulted in ≥ 50% reduction of mAb binding were mapped (shown in magenta and circled) onto the WNV E protein crystal structure. Epitopes are labeled using the nomenclature defined in Oliphant et al. (21).