Fig.1.

Chlordecone activates pregnane X receptor (human homolog). HEK 293 cells were cotransfected with the Gal4 luciferase reporter and a series of chimeras in which Gal4 DNA binding domain was fused to the indicated nuclear receptor ligand-binding domain. Cells were treated with ethanol or CD (0.1, 1, or 10 μM). Activation of nuclear receptors was assessed by measuring luciferase activity. Values were presented as the mean relative luciferase induction from triplicate assays±SE. Significant differences from ethanol controls detected as described in Materials and methods were indicated by an asterisk.