Table 3.
Multilineage engraftment of human hematopoietic cells in NOD/SCID mice
| Culture condition | Percentage of engrafted human CD45+ cell expressing:
|
||
|---|---|---|---|
| CD34 | CD19 | CD33 | |
| d 0 BM CD34+CD38−lin− cells | 8.9 ± 5.0 | 93.8 ± 3.3 | 7.1 ± 6.8 |
| d 7 LG1506 + TSF | 5.5 ± 5.5 | 91.8 ± 3.8 | 7.7 ± 2.7 |
NOD/SCID mice received transplants from 2.5 × 103 to 5 × 103 BM CD34+CD38−lin− cells or their progeny after 7 d culture with LG1506 plus TSF, as described in Materials and Methods. The numbers shown under the CD34, CD19, and CD33 columns indicate the mean percentage of engrafted human CD45+ cell that expressed that particular differentiation antigen (n = 5 mice analyzed per group).