Table 3.
Associations with INSIG2 rs7566605 phenotypes with baseline and percent (%) fat and strength change in FAMUSS cohort with resistance training.
| Phenotype | Gender | P-value | N; mean ± SEM | 95% CI | % variability attributable to genotype; LRT p-value |
| Baseline subcutaneous fat volume (mm3) | Female | 0.0011 | GG (N = 139; 243473 ± 5713) GC/CC (N = 181; 268521 ± 5003) |
GG (232233 – 254714) GC/CC (258677 – 278365) |
1.1%; 0.0010 |
| Baseline subcutaneous fat volume (mm3) | Male | 0.3557 | GG (N = 103; 176503 ± 6100) GC/CC (N = 94; 168275 ± 6389) |
GG (164472 – 188534) GC/CC (155675 – 180876) |
0.2%; 0.3501 |
| % change in subcutaneous fat volume | Female | 0.2683 | GG (N = 139; 11.20 ± 5.71) GC/CC (N = 181; 2.78 ± 4.99) |
GG (-0.02 – 22.43) GC/CC (-7.05 – 12.61) |
0.4%; 0.2649 |
| % change in subcutaneous fat volume | Male | 0.0353 | GG (N = 103; 1.00 ± 1.74) GC/CC (N = 94; 6.39 ± 1.82) |
GG (-2.43 – 4.43) GC/CC (2.78 – 10.01) |
2.3%; 0.0332 |
All genetic models were dominant.