Table 1.

Overview of GAPDH expression in different tumor and non-tumor cell lines as a consequence of the development of a hypoxic cellular microenvironment.

Cell line or type	Origin	Genetic mutations	GAPDH overexpression	Ref.	Ref.
		(-/+)	under hypoxia	GAPDH	mutations
U373 – MG	Malignant glioma cells (Human)	-Apoptosis resistant mutant P53	(-)	[24,25]	[40],
		-Peroxisome proliferator activated receptor – γ
		-PTEN mutation			[41],
GaMG	Malignant glioma cells (Human)	(-)	(-)	[24,25]	[33], [41]
U251	malignant glioma cells (Human)	Mutated p53	(-)	[24,25]	[40]
		P14ARF/P16 deletion
Bovine articular chondrocytes	Chondrocytes (Bovine)	Not determined	(-)	[37]	(-)
LNCap	Prostate adenocarcinoma cells	(-)	(+)	[34]	[27]
	(Human)
ATII	Alveolar epithelial cells (Rat)	(-)	(+)	[26]	[26]
SiHA	Spontaneous cervical cancer cells (Human)	(-)	(+)	[35]	[36]
		Wild type p53
MBEC4	Brain capillary endothelial cells	(-)	(+)	[37]	[37]
	(Mouse)
EC	Endothelial cells (Human)	- Not determined	(+)	[5], [22], [23], [24,39], [39]	[39]
		- Mutated epithelial cells are present
HepG2	Human Hepatocellular Carcinoma	Raf inactive (-)	(-)	[This Paper]	[42], [43]
		Wild type p53
		Wild type Retinoblastoma
Hep-3-B	Human Hepatocellular Carcinoma	Wild type p53	(-)	[This Paper]	[43,44]
		Absence of RB transcripts
		Deletion p53 gene
Hep.1-6	Mouse Hepatocellular Carcinoma	- Not determined	(-)	[This Paper]	[45]
HCT-116	Colon cancer cell line (Human)	K-ras (+)	(-)	(-)	[46]
HT-29	Colon cancer cell line (Human)	(-)	(-)	(-)	[46], [47]
A-549	Lung cancer cell line (Human)	k-Ras (+)	(-)	(-)	[47], [48]
		c-RAS (+)