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. Author manuscript; available in PMC: 2010 Feb 18.
Published in final edited form as: Neuroscience. 2008 Dec 7;158(4):1577–1588. doi: 10.1016/j.neuroscience.2008.11.039

Fig. 4.

Fig. 4

Lack of effect of KCNQ channel blocker XE991 or the adenylate cyclase inhibitor MDL12230A on oxotremorine-M-induced increases in sIPSCs of lamina II neurons. A, Raw traces of GABAergic sIPSCs of one lamina II neuron during control, application of 3 μM oxotremorine-M (oxo-M), 10 μM XE991 alone, and XE991 plus oxotremorine-M. B, Cumulative distribution plots of the inter-event interval and amplitude of sIPSCs of the same neuron in A during control and application of oxotremorine-M with and without XE991. C, Summary data show that 10 μM XE991 had no significant effect on oxotremorine-M-induced increase in the frequency of sIPSCs of 9 lamina II neurons. D, Summary data show that 20 μM MDL12230A (MDL) had no effect on oxotremorine-M-induced increases in the frequency of sIPSCs of another 10 neurons. Data are presented as means ± S.E.M. *, P < 0.05 compared with the pre-drug control. #, P < 0.05 compared with the initial baseline control.