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. Author manuscript; available in PMC: 2010 Feb 18.
Published in final edited form as: Neuroscience. 2008 Dec 7;158(4):1577–1588. doi: 10.1016/j.neuroscience.2008.11.039

Fig. 5.

Fig. 5

Effect of pre-incubation of the spinal slices with the PI3K inhibitor wortmannin or LY294002 on oxotremorine-M-induced increase in GABAergic sIPSCs of lamina II neurons. A, Representative traces of sIPSCs during control and application of 3 μM oxotremorine-M (oxo-M) in one lamina II neuron after wortmannin (100 nM) treatment. B, Cumulative distribution plots of the inter-event interval and amplitude of sIPSCs of the same neuron in A. C and D, Summary data show the effect of oxotremorine-M on the frequency of GABAergic sIPSCs of lamina II neurons pretreated with 100 nM wortmannin or 50 μM LY294002. Data are presented as means ± S.E.M. *, P < 0.05 compared with the respective controls.