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. 2008 Jun 21;21(7):1384–1395. doi: 10.1021/tx8000303

Table 1. Nucleophilic Functional Groups in LDL.

residue total reactive
lysine ϵ-NH2 350 225a
EPs 80 80
histidine 115 115 (maximum)
cysteine 25 25 (maximum)
total 570 445
a

TNBS reactive amino groups are 317 ± 29 and include all “reactive” (toward both TNBS and formaldehyde) lysines and all EPs or approximately 225 + 80 = 305. Maximum possible values are indicated since the number of “reactive” histidine and cysteine residues is unknown (41).