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Effect of M119 on morphine-induced physical dependence. In a measure of acute morphine dependence, mice were administered morphine (100 mg/kg, s.c., −4 h) and withdrawal was precipitated by injection of naloxone (10 mg/kg, i.p.). Withdrawal jumping was counted for 15 min after antagonist injection. Injection of M119 (100 nmol, i.c.v.) 30 min before the injection of naloxone resulted in significantly less vertical jumps than naloxone alone (*p < 0.05).
