Table 2.

Association between IGF-1 and IGF-2 haplotypes and breast cancer risk.

	Frequency
Haplotype	Cases (n=1,055)	Controls (n=1,059)	Odds ratio (95% CI)*
IGF-1
block 1†
TCCA	38.1	37.8	1.0
CCCA	15.8	16.1	1.0 (0.8–1.2)
CCTC	28.1	27.9	1.0 (0.9–1.2)
CTTA	16.5	16.7	0.9 (0.7–1.1)
block 2‡
TT	56.6	55.9	1.0
TC	18.0	18.0	1.0 (0.8–1.2)
CC	25.2	25.6	1.0 (0.8–1.1)
block 3§
CG	26.2	27.4	1.0
CC	58.2	56.7	0.8 (0.5–1.4)
TG	15.6	15.9	1.0 (0.5–2.1)
block 4∥
AC	66.1	64.3	1.0
AT	5.9	6.0	1.0 (0.7–1.3)
TT	27.5	28.5	0.9 (0.8–1.1)
IGF-2
Block 1**
TCC	55.2	57.3	1.0
CCT	24.2	23.3	1.1 (0.8–1.7)
CTC	16.7	15.8	1.1 (0.9–1.3)

^*Additive model, adjusted for age, menopausal status, age at menarche, and age at first full term pregnancy

^†rs10860861, rs6219, rs2946834, and rs5742726

^‡rs6218 and rs6220

^§rs4764697 and rs2195239

^∥rs2288377 and rs35767

^**rs2558, rs3802971, and rs734351