Table 3.
Gene loci and related MS. Nine of the 18 MS tested were significantly associated with HCC recurrence.
Locus | Gene | Microsatellite | GenBank | % non-informative | % AI overall | % AI Milan=no | %AI Milan=yes | %AI recur=yes | %AI recur=no | p value |
---|---|---|---|---|---|---|---|---|---|---|
1p34.2 | L-MYC | MYCL 5NT | M19720 | 24.3% | 34.0% | 57.7% | 11.1% | 75.0% | 9.1% | <0.0001 |
1p36.21 | ** | D1S407 | L18040 | 28.6% | 36.0% | 53.6% | 13.6% | 60.0% | 20.0% | 0.0016 |
3p24.3 | OGG! | D3S2303 | L17972 | 28.6% | 34.0% | 44.0% | 24.0% | 60.0% | 22.9% | 0.0085 |
3p26.3 | OGG1 | D3S1539 | L16393 | 21.4% | 29.1% | 36.7% | 20.0% | 52.4% | 14.7% | 0.0026 |
5q21 | MCC | MCC E10 | M62397 | 37.1% | 11.4% | 14.3% | 8.7% | 21.4% | 6.7% | 0.2 |
5q23.1 | APC | D5S592 | L16423 | 24.3% | 34.0% | 40.0% | 28.5% | 38.9% | 31.4% | 0.57 |
5q23.2 | APC | D5S615 | L18737 | 24.3% | 24.5% | 31.0% | 16.7% | 36.8% | 17.7% | 0.09 |
7q22.3 | MET | D7S1530 | L30387 | 22.9% | 22.2% | 16.0% | 27.6% | 16.7% | 25.0% | 0.46 |
8q24.3 | C-MYC | D8S373 | L16320 | 25.7% | 23.1% | 33.3% | 14.3% | 41.2% | 14.3% | 0.024 |
9p21.1 | CDKN2A | D9S251 | L18726 | 25.7% | 17.3% | 24.0% | 11.1% | 25.0% | 13.9% | 0.29 |
9p23 | CDKN2A | D9S254 | L18040 | 17.1% | 31.0% | 43.3% | 17.9% | 42.9% | 24.3% | 0.12 |
10q23.33 | PTEN | D10S520 | L16357 | 28.6% | 20.0% | 20.8% | 19.2% | 35.7% | 13.9% | 0.06 |
10q23.32 | PTEN | D10S1173 | L30341 | 25.7% | 30.8% | 30.8% | 30.7% | 42.1% | 24.2% | 0.14 |
17p12 | TP53 | D17S1289 | G09615 | 17.1% | 10.3% | 15.2% | 4.0% | 22.7% | 2.8% | 0.0031 |
17p12 | TP53 | D17S974 | G07961 | 22.9% | 20.4% | 33.3% | 7.4% | 40.0% | 8.8% | 0.0006 |
17p13.1 | TP53 | TP53 L1 | M13121 | 38.6% | 11.6% | 11.1% | 12.0% | 11.1% | 11.8% | 0.98 |
17q25.1 | ** | D17S1163 | L30445 | 18.6% | 14.0% | 24.1% | 3.6% | 31.6% | 5.3% | 0.0022 |
18q21.33 | DCC | D18S814 | L17776 | 34.3% | 47.8% | 72.7% | 25.0% | 80.0% | 32.3% | 0.0022 |
no known tumor-related gene at these loci