Table 5.
Univariate and multivariate analyses of predictors of recurrence in 35 patients with tumors beyond Milan Criteria.
| Recurrence (n=21) |
No recurrence (n=14) |
p(log-rank) | |
|---|---|---|---|
| Univariate | |||
| Histologic differentiation* | |||
| Well/moderate | 15 | 13 | .08 |
| Poor | 5 | 1 | |
| Vascular invasion | |||
| None | 1 | 4 | |
| Microscopic | 10 | 8 | .007** |
| Macroscopic | 10 | 2 | |
| Alpha-fetoprotein | |||
| < 1000 ng/ml | 12 | 10 | .31 |
| ≥ 1000 ng/ml | 9 | 4 | |
| FAI | |||
| < .27 | 1 | 10 | .0002 |
| ≥ .27 | 20 | 4 | |
| Multivariate analysis | Hazard ratio (95% CI) | P | |
| FAI | 17.3 (2.3–130.5) | 0.006 | |
| Macroscopic VI | 3.0 (1.2–7.3) | 0.018 | |
*
1 case with missing histologic differentiation data
**
None/Microscopic vs Macroscopic