Table III.
Ontologies significantly impacted by LH and steroid ablation/replacementa
| Ontology | List | Array | z-score | %b |
|---|---|---|---|---|
| Immune system | ||||
| immunoglobulin production | 5 | 13 | 6.09 | 38 |
| regulation of B cell activation | 5 | 16 | 5.33 | 31 |
| production of molecular mediator of immune response | 5 | 22 | 4.27 | 23 |
| cellular defense response | 10 | 53 | 5.25 | 19 |
| B cell activation | 8 | 46 | 4.40 | 17 |
| response to inorganic substance | 5 | 29 | 3.45 | 17 |
| leukocyte differentiation | 9 | 71 | 3.50 | 13 |
| immune system development | 13 | 135 | 3.08 | 10 |
| negative regulation of immune system process | 6 | 27 | 4.61 | 22 |
| Steroid/cholesterol processes/metabolism | ||||
| sterol biosynthetic process | 11 | 30 | 8.77 | 37 |
| cholesterol biosynthetic process | 8 | 23 | 7.23 | 35 |
| steroid biosynthetic process | 17 | 62 | 9.02 | 27 |
| sterol metabolic process | 16 | 68 | 7.86 | 24 |
| cholesterol metabolic process | 13 | 61 | 6.58 | 21 |
| steroid metabolic process | 26 | 142 | 8.30 | 18 |
| lipid biosynthetic process | 32 | 222 | 7.53 | 14 |
| Cellular morpohology | ||||
| regulation of cell shape | 5 | 31 | 3.26 | 16 |
| regulation of cell morphogenesis | 5 | 32 | 3.17 | 16 |
| cell-substrate adhesion | 10 | 70 | 4.14 | 14 |
| myeloid cell differentiation | 8 | 58 | 3.58 | 14 |
| cell-matrix adhesion | 9 | 66 | 3.76 | 14 |
| chemotaxis | 11 | 100 | 3.33 | 11 |
| taxis | 11 | 100 | 3.33 | 11 |
| Cellular metabolism/biosynthesis | ||||
| isoprenoid metabolic process | 5 | 25 | 3.88 | 20 |
| oxygen and reactive oxygen species metabolic process | 6 | 31 | 4.15 | 19 |
| water-soluble vitamin metabolic process | 7 | 37 | 4.40 | 19 |
| oxidoreduction coenzyme metabolic process | 5 | 31 | 3.26 | 16 |
| vitamin metabolic process | 8 | 55 | 3.76 | 15 |
| cofactor metabolic process | 15 | 122 | 4.39 | 12 |
| membrane lipid biosynthetic process | 10 | 83 | 3.50 | 12 |
| coenzyme metabolic process | 12 | 100 | 3.82 | 12 |
| alcohol metabolic process | 27 | 228 | 5.69 | 12 |
| cellular lipid metabolic process | 52 | 472 | 7.39 | 11 |
| glycoprotein biosynthetic process | 12 | 110 | 3.45 | 11 |
| glycoprotein metabolic process | 14 | 131 | 3.64 | 11 |
| protein amino acid glycosylation | 11 | 103 | 3.22 | 11 |
| biopolymer glycosylation | 11 | 105 | 3.15 | 10 |
| fatty acid metabolic process | 14 | 141 | 3.33 | 10 |
| isoprenoid biosynthetic process | 5 | 15 | 5.56 | 33 |
| Signal transduction | ||||
| activation of phospholipase C activity | 2 | 12 | 2.12 | 17 |
| peptidyl-tyrosine modification | 5 | 36 | 2.85 | 14 |
| positive regulation of I-kappaB kinase/NF-kappaB cascade | 9 | 78 | 3.17 | 12 |
az-score ≥3.0, as determined by GeneSifter© Software Analysis and ≥5 transcripts per ontology, with significant transcripts representing at least 10% of ontology on array.
b% determined by number of transcripts in ontology list divided by total number of transcripts in ontology on array.