Table 4.

Test Characteristics for NT-proBNP and BNP for the Detection of Left Ventricular Systolic Dysfunction in the Total Population and Subgroups

				NT-proBNP				BNP
Population	EF	n	p*	AUC	Cutpoint†	Sens	Spec	AUC	Cutpoint†	Sens	Spec
All (n = 1,869)	≤ 40	37	0.0087	0.94	228	86.5	86.0	0.89	66	81.1	81.1
	≤50	115	< 0.0001	0.78	129	73.9	73.8	0.72	40	68.7	68.7
Age ≥65 yrs (n = 747)	≤40	26	0.0360	0.92	452	88.5	88.4	0.87	97	76.9	76.9
	≤50	70	0.0011	0.85	233	75.7	75.7	0.79	73	71.4	71.4
Age <65 yrs (n = 1,122)	≤40	11	0.0912	0.96	163	90.9	90.9	0.88	42	81.8	81.8
	≤50	45	< 0.0001	0.65	59	62.2	61.3	0.56	19	55.6	55.5
All men (n = 907)	≤40	29	0.0152	0.95	209	86.2	87.4	0.91	55	82.8	82.4
	≤50	85	< 0.0001	0.80	92	75.3	74.8	0.73	28	70.6	70.2
All women (n = 962)	≤40	8‡	0.8107	0.91	372	83.3	83.3	0.94	102	87.5	87.5
	≤50	30	0.0908	0.83	246	75.0	73.1	0.77	57	73.3	73.3
Men, age ≥65 yrs (n = 350)	≤40	20	0.0718	0.93	462	85.7	88.0	0.89	79	75.0	75.9
	≤50	50	0.0036	0.88	211	79.2	79.4	0.82	61	72.0	72.1
Women, age ≥65 yrs (n = 397)	≤40	6‡	0.5178	0.91	372	83.3	83.3	0.88	124	83.3	81.0
	≤50	20	0.1867	0.83	246	75.0	73.1	0.78	79	70.0	69.7
Men, age < 65 yrs (n = 557)	≤40	9‡	0.0921	0.97	109	88.9	90.0	0.90	24	77.8	77.7
	≤50	35	0.0002	0.69	32	62.9	62.8	0.58	12	57.1	56.7
Women, age < 65 yrs (n = 565)	≤40	2‡	0.3627	0.97	245	100	94.3	0.98	108	100	96.4
	≤50	10	0.0278	0.75	105	70.0	69.9	0.64	30	60.0	60.0

^*p for comparison of AUCs for NT-proBNP and BNP.

^†The NT-proBNP or BNP concentration (pg/ml) resulting in a sensitivity and specificity closest to 100%.

^‡Note the limited number of subjects with EF ≤40% in this subgroup.

AUC = area under the curve; EF = ejection fraction; NT-proBNP = amino-terminal pro-B-type natriuretic peptide; Sens = sensitivity; Spec = specificity.