Table 5.
Test Characteristics for NT-proBNP and BNP for the Detection of Systolic Dysfunction in the Total Population and Subgroups
| Population | EF | +LR* | −LR* | % Screened Needing Echocardiogram* | % Echocardiograms That Are Negative* | % With Disease Missed* | Odds Ratio* |
|---|---|---|---|---|---|---|---|
| All | ≤40 | 6.2/4.3 | 0.16/0.23 | 15.4/20.1 | 88.9/92.0 | 13.5/18.9 | 39.4/18.4 |
| ≤50 | 2.8/2.2 | 0.35/0.46 | 29.1/33.6 | 84.4/87.4 | 26.1/31.3 | 8.0/4.8 | |
| Age ≥65 yrs | ≤40 | 7.6/3.3 | 0.13/0.30 | 12.7/23.9 | 89.8/95.3 | 11.5/23.1 | 58.6/11.1 |
| ≤50 | 3.1/2.5 | 0.32/0.40 | 29.1/32.6 | 75.6/79.5 | 24.3/28.6 | 9.7/6.2 | |
| Age < 65 yrs | ≤40 | 10.0/4.5 | 0.10/0.22 | 11.0/19.7 | 80.8/90.4 | 9.1/18.2 | 99.8/20.2 |
| ≤50 | 1.6/1.2 | 0.62/0.80 | 39.6/44.9 | 93.7/95.0 | 37.8/44.4 | 2.6/1.6 | |
| All men | ≤40 | 6.8/4.7 | 0.16/0.21 | 15.0/19.7 | 81.6/86.6 | 13.8/17.2 | 43.3/22.5 |
| ≤50 | 3.0/2.4 | 0.33/0.42 | 29.9/33.6 | 76.4/80.3 | 24.7/29.4 | 9.0/5.7 | |
| All women | ≤40 | 5.0/7.0 | 0.20/0.14 | 17.3/13.1 | 96.0/94.5 | 16.7/12.5 | 24.9/49.0 |
| ≤50 | 2.8/2.7 | 0.34/0.36 | 28.4/28.2 | 91.8/91.9 | 25.0/26.7 | 8.2/7.5 | |
| Men, age ≥65 yrs | ≤40 | 7.1/3.1 | 0.16/0.33 | 16.2/27.0 | 69.8/84.1 | 14.3/25.0 | 43.9/9.4 |
| ≤50 | 3.8/2.6 | 0.26/0.39 | 29.0/34.2 | 60.9/69.9 | 20.8/28.0 | 14.7/6.6 | |
| Women, age ≥65 yrs | ≤40 | 5.0/4.4 | 0.20/0.20 | 17.7/20.0 | 92.9/93.7 | 16.7/16.7 | 24.9/21.3 |
| ≤50 | 2.8/2.3 | 0.34/0.43 | 29.3/32.3 | 87.1/89.0 | 25.0/30.0 | 8.2/5.4 | |
| Men, age < 65 yrs | ≤40 | 8.9/3.5 | 0.12/0.29 | 11.3/23.2 | 87.3/94.6 | 11.1/22.2 | 72.1/12.2 |
| ≤50 | 1.7/1.3 | 0.59/0.76 | 38.8/44.2 | 89.8/91.9 | 37.1/42.9 | 2.9/1.7 | |
| Women, age < 65 yrs | ≤40 | 17.5/27.8 | 0/0 | 6.0/3.9 | 94.1/91.0 | 0/0 | –/– |
| ≤50 | 2.3/1.5 | 0.43/0.67 | 30.8/40.4 | 95.8/97.4 | 30.0/40.0 | 5.4/2.3 |
*
NT-proBNP/BNP.
EF = ejection fraction; +LR = positive likelihood ratio; −LR = negative likelihood ratio.