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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Pharmacol Biochem Behav. 2008 Dec 7;92(1):190–196. doi: 10.1016/j.pbb.2008.11.011

Fig. 1.

Fig. 1

Mean (± SE) paw-lick latency of morphine (0, 2.5, 5.0, or 10.0 mg/kg, SC) treated male and female rats (N = 265) on the hot-plate task (data expressed as % of maximal possible effect). Rats were pretreated with saline or methylphenidate (2.0 or 5.0 mg/kg, IP) from PD 11 to PD 20 and tested with morphine on PD 60. Data in this figure are collapsed across the early methylphenidate exposure condition.

aSignificantly different from saline-treated rats of the same sex.

bSignificantly different from similarly treated male rats.