Table 1.
Differentially Expressed Genes from Microarray Analysis of Murine Primary Cortical Neurons Treated with 1 µM Lactacystin
| Genbank No. | Gene Title | Gene Symbol | 4.5h | 7.5h | 24h | 48h |
|---|---|---|---|---|---|---|
| Water channels | ||||||
| U88623 | Aquaporin 4 | Aqp4 | -1.59 ± 0.08 | -6.24 ± 0.09 | -6.17 ± 0.1 | 1.22 ±0.16 |
| Na+/K+ ATPase | ||||||
| AW123952 | ATPase, Na+/K+ transporting, alpha 1 polypeptide | Atp1a1 | -1.26 ± 0.1 | 2.16 ± 0.09 | 1.13 ± 0.18 | 1.46 ± 0.14 |
| AI829697 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | Atp1a2 | 1.02 ± 0.08 | -1.64 ± 0.07 | -3.57 ± 0.09 | -1.03 ± 0.26 |
| Chloride channels | ||||||
| AF029347 | Chloride channel 3 | Clcn3 | 2.23 ± 0.07 | 1.76 ± 0.07 | 1.14 ± 0.1 | -1.26 ± 0.16 |
| AF109905 | Chloride intracellular channel 1 | Clic1 | 1.45 ± 0.11 | 1.76 ± 0.09 | 3.64 ± 0.18 | 3.2 ± 0.45 |
| Ionotropic receptors | ||||||
| L32372 | Glutamate receptor, ionotropic, AMPA2 (alpha2) | Gria2 | 2.13 ± 0.07 | 1.18 ± 0.09 | -1.15 ± 0.11 | -1.18 ± 0.11 |
| D10028 | Glutamate receptor, ionotropic, NMDA1 (zeta1) | Grin1 | -1.02 ± 0.13 | 2.3 ± 0.1 | -1.68 ± 0.16 | -1.73 ± 0.17 |
| Potassium channels | ||||||
| AI850484 | Potassium voltage-gated channel, shaker-related subfamily, member 3 | Kcna3 | 2.06 ± 0.16 | 1.22 ± 0.12 | -1.16 ± 0.1 | -1.14 ± 0.12 |
| AB000503 | Potassium voltage-gated channel, subfamily Q, member 2 | Kcnq2 | -2.33 ± 0.08 | -1.9 ± 0.07 | 1.03 ± 0.15 | -1.24 ± 0.1 |
| Solute carrier families | ||||||
| D43797 | Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | Slc1a1 | 1.15 ± 0.25 | 1.88 ± 0.17 | -2.14 ± 0.15 | -2.42 ± 0.15 |
| U75215 | Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | Slc1a4 | 1.4 ± 0.06 | 2.41 ± 0.1 | -1.03 ± 0.26 | -1.52 ± 0.1 |
| AA062013 | Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | Slc25a5 | -1.64 ± 0.08 | -2.59 ± 0.06 | -1.06 ± 0.17 | 1.06 ± 0.13 |
| U76009 | Solute carrier family 30 (zinc transporter), member 3 | Clc30a3 | -2.52 ± 0.08 | -2.06 ± 0.07 | -1.26 ± 0.11 | -1.2 ± 0.1 |
| AV278013 | Solute carrier family 4, sodium bicarbonate cotransporter, member 7 | Slc4a7 | -3.75 ± 0.07 | -2.01 ± 0.07 | -1.12 ± 0.1 | 1.02 ± 0.16 |
| AF020195 | Solute carrier family 4 (anion exchanger), member 4 | Slc4a4 | -1.3 ± 0.13 | -3.96 ± 0.11 | -1.48 ± 0.13 | 1.46 ± 0.15 |
| AV230927 | Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | Slc6a4 | -1.56 ± 0.12 | -2.23 ± 0.08 | -1.93 ± 0.13 | 1.25 ± 0.13 |
| U25739 | Solute carrier family 23 (nucleobase transporters), member 3 | Slc23a3 | -2.48 ± 0.12 | -2.94 ± 0.08 | -1.25 ± 0.1 | -1.36 ± 0.1 |
| AW048729 | Solute carrier family 5 (sodium-dependent vitamin transporter), member 6 | Slc5a6 | -2.48 ± 0.07 | -2.76 ± 0.08 | -1.3 ± 0.13 | -1.24 ± 0.12 |