Table 1.
Published Randomized Clinical Trials of Atypical Antipsychotics among Patients with BPSD
| Trial | Intervention | Daily Dose | Population | Setting | Duration (Weeks) | Primary Efficacy Measure |
|---|---|---|---|---|---|---|
| Katz,1999 [52] | risperidone vs placebo | Fixed,0.5,1.0 or 2.0 mg | N=625;AD,VaD, mixed | Nursing home | 12 | BEHAVE-AD |
| De Deyn 1999 [23] | risperidone vs haloperidolvs placebo | Flexible, mean risperidone 1.1 mg, mean haloperidol 1.2 mg | N=344;AD, VaD, mixed | Nursing home | 13 | BEHAVE-AD,CMAI, CGI |
| Brodaty, 2003 [13] | risperidone vs placebo | Flexible, mean 0.95 mg | N=309;AD, VaD, mixed | Nursing home | 12 | CMAI, BEHAVE-AD, CGI |
| Street, 2000 [80] | olanzapine vs placebo | Fixed, 5.0, 10.0 or 15.0 mg | N=206; AD | Nursing home | 6 | NPI-NH |
| De Deyn,2004 [22] | olanzapine vs placebo | Fixed,1.0, 2.5, 5.0 or 7.5mg | N=652;AD | Nursing home | 10 | NPI-NH |
| Deberdt,2005 [24] | olanzapine vs placebo vsrisperidone | Flexible, mean olanzapine 5.2 mg, mean risperidone 1.0 mg | N=298; AD, VaD,mixed | Outpatient and residential | 10 | NPI, CGI |
| Ballard,2005 [4] | quetiapine vs rivastigmine vsplacebo | Flexible,range quetiapine 50-100 mg | N=93;AD | Nursing home | 26 | CMAI,SIB |
| De Deyn, 2005 [21] | aripiprazole vs placebo | Fixed, 5, 10 or 15 mg | N=208; AD | Outpatient | 10 | NPI, BPRS |
| Schneider, 2006 [76] | olanzapine vs quetiapinevs risperidone vs placebo | Flexible, mean olanzapine 5.5 mg, mean quetiapine 56.5 mg, mean risperidone 1.0 mg) | N=421; AD | Outpatient | 36 | Time from initial treatment to discontinuation/CGIC |
| Zhong, 2007 [90] | quetiapine vs. placebo | Fixed, 100 or 200 mg | N=333; AD | Nursing home | 10 | PANSS-EC, CGI,NPI-NH, CMAI |
| Kurlan, 2007[53] | quetiapine vs. placebo | Flexible, mean 120 mg | N=40; DLB, PD, AD | Outpatient | 10 | BPRS |
Abbreviations: AD= Alzheimer’s disease; VaD=Vascular dementia; DLB=Dementia with Lewy Bodies; PD= Parkinson disease with dementia; BEHAVE-AD=Behavioral Pathology in Alzheimer’s disease rating scale; CMAI= Cohen-Mansfield Agitation Inventory; CGI=Clinical Global Impression; NPI= Neuropsychiatric Inventory; NPI-NH=Neuropsychiatric Inventory –nursing home version; SIB= severe impairment battery; BPRS= Brief Psychiatric Rating Scale; CGIC=Clinical Global Impression of Change; PANSS-EC= positive and negative syndrome scale-excitement component.