Table 1.

Summary of Data on the Effects of the Myostatin Binding Proteins

	In Vitro	Animal	Human
Myostatin propeptide	Antagonizes myostatin biological activity by inhibiting myostatin receptor binding [2]	Overexpression of propeptide associated with increased muscle mass [13, 14]
FLRG	Inhibits myostatin activity in signalling assays, maintains myostatin latency [11]	Overexpression of FLRG associated with increased muscle mass [15]
GASP 1	Inhibits myostatin activity in signalling assays, maintains myostatin latency [12]
hSGT	Inhibits myostatin activity in signalling assays [10]
Titin-cap (telethonin)	Myoblasts overexpressing titin-cap associated with increased myoblast proliferation, regulates myostatin secretion [9]		Lack of functional Titin-cap protein is responsible for a rare limb girdle muscular Dystrophy type 2G [17]
Follistatin	Inhibits myostatin receptor binding, antagonizes myostatin inhibition of myogenesis [7]	Overexpression of follistatin associated with increased muscle mass [13]; Loss of Follistatin associated with reduced muscle mass [16]
Decorin	Blocks the inhibitory effect of myostatin on proliferation of muscle cells [8]